One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …

Immunotherapy based on immune checkpoint inhibitors has evolved into a new pillar of
cancer treatment in clinics, but dealing with treatment resistance (either primary or acquired) …

Biomembranes constitute a basis for all compartments of live cells, and therefore, the
monitoring of their lipid organization is essential for understanding cell status and activity …

Acidity-stimulated platforms have the potential to improve the specificity of cancer imaging
and therapy within the tumor microenvironment (pH 6.5–6.8). However, avoiding non …

Glioblastoma (GBM), the most common malignant primary brain cancer in adults, nearly
always becomes resistant to current treatments, including the chemotherapeutic …

Mesenchymal stem cells adopt differentiation pathways based upon cumulative effects of
mechanosensing. A cell's mechanical microenvironment changes substantially over the …

The lack of in vitro models that represent the native tumor microenvironment is a significant
challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the …

Mechanotransduction, the translation of mechanical stimuli into biological signals, is a
crucial mechanism involved in the function of fundamentally all cell types. In many solid …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Currently, one of the main reasons for the ineffectiveness of tumor treatment is that the
abnormally high tumor interstitial pressure (TIP) hinders the delivery of drugs to the tumor …