Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …

Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …

Childhood malignancies are rarely related to known environmental exposures, and it has
become increasingly evident that inherited genetic factors play a substantial causal role …

Clinicians are encouraged to document the reasons for the use of a particular procedure or
test, whether or not it is in conformance with this statement. Clinicians also are advised to …

Background Human-assisted reproductive technologies (ART) are a widely accepted
treatment for infertile couples. At the same time, many studies have suggested the …

A well-functioning placenta is essential for fetal and maternal health throughout pregnancy.
Using placental weight as a proxy for placental growth, we report genome-wide association …

Developing synchronous bilateral Wilms tumor suggests an underlying (epi) genetic
predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or …

PURPOSE Wilms tumor (WT) is associated with (epi) genetic predisposing factors affecting a
growing number of WT predisposing genes and loci, including those causing Beckwith …

In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …