Comorbidities, treatment, and pathophysiology in restless legs syndrome
Restless legs syndrome, also known as Willis-Ekbom disease, is a common neurological
condition whose manifestation is affected by complex environmental and genetic …
condition whose manifestation is affected by complex environmental and genetic …
[HTML][HTML] Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum
Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …
dopaminergic neurotransmission. In the present essay we first review the extensive …
[HTML][HTML] The endocannabinoid system as a target in cancer diseases: are we there yet?
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …
decade. The immense data load published on its dual role in both tumorigenesis and …
[HTML][HTML] G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)
G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …
signaling across the plasma membrane and a major class of drug targets. The canonical …
[HTML][HTML] Control of glutamate release by complexes of adenosine and cannabinoid receptors
Background It has been hypothesized that heteromers of adenosine A 2A receptors (A2AR)
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …
Heterobivalent Ligand for the Adenosine A2A–Dopamine D2 Receptor Heteromer
D Pulido, V Casado-Anguera… - Journal of medicinal …, 2022 - ACS Publications
AG protein-coupled receptor heteromer that fulfills the established criteria for its existence in
vivo is the complex between adenosine A2A (A2AR) and dopamine D2 (D2R) receptors …
vivo is the complex between adenosine A2A (A2AR) and dopamine D2 (D2R) receptors …
New developments on the adenosine mechanisms of the central effects of caffeine and their implications for neuropsychiatric disorders
Recent studies on interactions between striatal adenosine and dopamine and one of its
main targets, the adenosine A2A receptor–dopamine D2 receptor (A2AR–D2R) heteromer …
main targets, the adenosine A2A receptor–dopamine D2 receptor (A2AR–D2R) heteromer …
[HTML][HTML] Putative animal models of restless legs syndrome: A systematic review and evaluation of their face and construct validity
Restless legs syndrome (RLS) is a sensorimotor disorder that severely affects sleep. It is
characterized by an urge to move the legs, which is often accompanied by periodic limb …
characterized by an urge to move the legs, which is often accompanied by periodic limb …
Functional and Neuroprotective Role of Striatal Adenosine A2A Receptor Heterotetramers
In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …
Biased G Protein-Independent Signaling of Dopamine D1-D3 Receptor Heteromers in the Nucleus Accumbens
X Guitart, E Moreno, W Rea, M Sánchez-Soto… - Molecular …, 2019 - Springer
Several studies found in vitro evidence for heteromerization of dopamine D 1 receptors
(D1R) and D 3 receptors (D3R), and it has been postulated that functional D1R-D3R …
(D1R) and D 3 receptors (D3R), and it has been postulated that functional D1R-D3R …