Comorbidities, treatment, and pathophysiology in restless legs syndrome

C Trenkwalder, R Allen, B Högl, S Clemens… - The Lancet …, 2018 - thelancet.com
Restless legs syndrome, also known as Willis-Ekbom disease, is a common neurological
condition whose manifestation is affected by complex environmental and genetic …

[HTML][HTML] Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum

S Ferré, LI Sarasola, C Quiroz, F Ciruela - Neuropharmacology, 2023 - Elsevier
Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …

[HTML][HTML] The endocannabinoid system as a target in cancer diseases: are we there yet?

E Moreno, M Cavic, A Krivokuca, V Casadó… - Frontiers in …, 2019 - frontiersin.org
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

[HTML][HTML] G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)

S Ferré, F Ciruela, CW Dessauer… - Pharmacology & …, 2022 - Elsevier
G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …

[HTML][HTML] Control of glutamate release by complexes of adenosine and cannabinoid receptors

A Köfalvi, E Moreno, A Cordomí, NS Cai… - BMC biology, 2020 - Springer
Background It has been hypothesized that heteromers of adenosine A 2A receptors (A2AR)
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …

Heterobivalent Ligand for the Adenosine A2A–Dopamine D2 Receptor Heteromer

D Pulido, V Casado-Anguera… - Journal of medicinal …, 2022 - ACS Publications
AG protein-coupled receptor heteromer that fulfills the established criteria for its existence in
vivo is the complex between adenosine A2A (A2AR) and dopamine D2 (D2R) receptors …

New developments on the adenosine mechanisms of the central effects of caffeine and their implications for neuropsychiatric disorders

S Ferré, M Díaz-Ríos, JD Salamone… - Journal of Caffeine and …, 2018 - liebertpub.com
Recent studies on interactions between striatal adenosine and dopamine and one of its
main targets, the adenosine A2A receptor–dopamine D2 receptor (A2AR–D2R) heteromer …

[HTML][HTML] Putative animal models of restless legs syndrome: A systematic review and evaluation of their face and construct validity

A Silvani, I Ghorayeb, M Manconi, Y Li, S Clemens - Neurotherapeutics, 2023 - Elsevier
Restless legs syndrome (RLS) is a sensorimotor disorder that severely affects sleep. It is
characterized by an urge to move the legs, which is often accompanied by periodic limb …

Functional and Neuroprotective Role of Striatal Adenosine A2A Receptor Heterotetramers

S Ferré, F Ciruela - Journal of Caffeine and Adenosine Research, 2019 - liebertpub.com
In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …

Biased G Protein-Independent Signaling of Dopamine D1-D3 Receptor Heteromers in the Nucleus Accumbens

X Guitart, E Moreno, W Rea, M Sánchez-Soto… - Molecular …, 2019 - Springer
Several studies found in vitro evidence for heteromerization of dopamine D 1 receptors
(D1R) and D 3 receptors (D3R), and it has been postulated that functional D1R-D3R …