Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …

Abstract Knowledge of how the joint functions as an integrated unit in health and disease
requires an understanding of the stromal cells populating the joint mesenchyme, including …

Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the
pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been …

Magnetic resonance (MR) imaging is very important for noninvasive lymphography.
However, the present MR contrast agents still cannot supply strong enough tissue contrast …

Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues
and also have roles in immune tolerance. Given the functional association of the lymphatics …

The lymphatics play important roles in chronic diseases/conditions that comprise the bulk of
healthcare worldwide. Yet the ability to routinely image and diagnose lymphatic dysfunction …

Recent reports have highlighted the role of the lymphatic system and its resident immune
cells in the development of inflammatory arthritis. Directing therapeutics to the joint-draining …

Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of
irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck …

Objective Recent studies have demonstrated that there is an inverse relationship between
lymphatic egress and inflammatory arthritis in affected joints. As a model, tumor necrosis …

Interstitial lung disease (ILD) is a well-known extra-articular manifestation of rheumatoid
arthritis (RA). RA-associated ILD (RA-ILD) exists on a wide spectrum, with variable levels of …