Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

The sensation of pain plays a critical role as an alert and as a protection system against
tissue damage from mechanical, chemical, and thermal stimuli. Despite the protective role of …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

It is considered that the site of action of the abortive antimigraine compounds acting at
serotonin, 5‐HT1B/1D, receptors (triptans) is the trigeminovascular system. We tested …

A long line of studies emphasizes the contribution of serotonergic fibres descending from the
rostral ventromedial medulla in the control of spinal nociceptive information processing. A …

Objectives: The purpose was to examine central inhibitory mechanisms involved in
analgesia produced by wheel running. Methods: C57/Black6 mice were given access to …

The impact of early life events is increasingly becoming apparent, as studies investigate how
early childhood can shape long‐term physiology and behaviour. Fibromyalgia (FM), which is …

Chronic tactile allodynia and hyperalgesia are frequent complications of spinal cord injury
(SCI) with poorly understood mechanisms. Possible causes are plastic changes in the …

Background: Despite the extensive number of studies performed in the last 50 years, aimed
at describing the role of serotonin and its receptors in pain modulation at the spinal cord …

This review shows that the role of 5‐hydroxytryptamine (5‐HT) in the regulation of
nociception depends on the 5‐HT receptor subtypes involved and on long‐term functional …