Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on
glucose metabolism, causes functional impairments in several metabolic pathways, both in …

Significance: The endoplasmic reticulum (ER) is a specialized organelle for the folding and
trafficking of proteins, which is highly sensitive to changes in intracellular homeostasis and …

The arrangement of β cells within islets of Langerhans is critical for insulin release through
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Diabetes mellitus is increasing at an alarming rate and has become a global challenge.
Insulin resistance in target tissues and a relative deficiency of insulin secretion from …

Execution of fundamental cellular functions demands regulated protein folding homeostasis.
Endoplasmic reticulum (ER) is an active organelle existing to implement this function by …

The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its “incretin effect”
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …

The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …