T cells, the critical immune cells of the adaptive immune system, are often dysfunctional in
Alzheimer's disease (AD) and are involved in AD pathology. Reports highlight …

Background and Aims The relationship between serum cholesterol level and development
of hepatocellular carcinoma (HCC) remains unclear. We investigated the effects of serum …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show
that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell …

Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by the
production of abnormal autoantibodies and immune complexes that can affect the organ and …

Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a
key regulator of SREBP maturation. SCAP induces translocation of SREBP from the …

Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most
prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein …

The activation of liver X receptor (LXR) promotes cholesterol efflux and repression of
inflammatory genes with anti-atherogenic consequences. The mechanisms underlying the …

Millions of people worldwide have diabetes, which is diagnosed by fasting blood glucose
levels exceeding 126 mg/dL. Regardless of the type of diabetes, prolonged hyperglycemia …

Inflammation represents the driving feature of many diseases, including atherosclerosis,
cancer, autoimmunity and infections. It is now established that metabolic processes shape a …