Advancing age is accompanied by significant remodelling of the immune system, termed
immune senescence, and increased systemic inflammation, termed inflammageing, both of …

Background: A hallmark of atherosclerosis is its complex pathogenesis, which is dependent
on altered cholesterol metabolism and inflammation. Both arms of pathogenesis involve …

Protein arginine methyltransferases (PRMTs) are widely found in eukaryotes and regulate
gene expression and post‑translational modifications. PRMT1‑PRMT6 have important roles …

Curative therapies against autoimmune diseases are lacking. Indeed, most of the currently
available treatments are only targeting symptoms. We have developed a novel strategy for a …

Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally
associated with the development of autoimmune diseases. However, the mechanism by …

Liver X receptors (LXRs) are transcription factors from the nuclear receptor family that can be
pharmacologically activated by high-affinity agonists. LXR activation exerts a combination of …

Immune metabolism is a rapidly moving field. While most of the research has been
conducted to define the metabolism of healthy immune cells in the mouse, it is recognized …

Objective To explore the associations between metabolic syndrome (MetS) and its individual
components and the risk of rheumatoid arthritis (RA). Methods A total of 369,065 individuals …

Purpose Although predictive markers of immune checkpoint inhibitor (ICI)-based treatments
have been extensively studied, with the exception of programmed death ligand 1 (PD-L1) …

Cholesterol membrane content has a ubiquitous evolutionary f... : Current Opinion in Lipidology
Cholesterol membrane content has a ubiquitous evolutionary function in immune cell activation …