Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative,
behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine …

Nicotinic cholinergic receptors were measured in human frontal cortex using [3 H] nicotine
and [3 H] acetylcholine (in the presence of atropine) as receptor ligands. A parallel marked …

Different effects of normal aging on muscarinic and nicotinic receptor subtypes were
observed in postmortem brain tissue from different regions of the human brain. A significant …

Background Reductions in cholinergic function occur in Alzheimer disease (AD) and
dementia with Lewy bodies and correlate with cognitive decline. However, whether such …

The regional expression of mRNA for the nicotinic acetylcholine receptor (nAChR) subunits
α3, α4 and α7 was examined in postmortem brain tissues from controls and patients with …

A technique was developed, which made it possible to study the in vitro release of 3 H-
acetylcholine (3 H-ACh) from human post mortem brain tissue, collected with short post …

Accumulating evidence suggests that the detrimental effect of nicotine and tobacco smoke
on the central nervous system (CNS) is caused by the neurotoxic role of nicotine on blood …

Multiple nicotinic receptors seem to exist in brain as revealed by neurophysiological,
neurochemical, molecular and immunological studies. The mechanisms for their …

Brain nicotinic acetylcholine receptors (nAChR) are a class of ligand-gated channels
composed of α and β subunits with specific structural, functional and pharmacological …