Oral bioavailability requires absorption of drugs across the intestinal epithelium. This may be
mediated by either the paracellular and/or transcellular routes. Passive transcellular …

P-glycoprotein, a membrane-associated transport protein, has recently been recognised as
an important element of the intestinal epithelium. This paper summarises thein vivodata on …

Rationale The multidrug resistance transporter, P-glycoprotein (P-gp), is involved in efflux
transport of several antipsychotics in the blood–brain barrier (BBB). Objectives In the present …

Drug interactions are ubiquitous but those with proven clinical relevance are much less
common. Only when the combined effects of the interacting drugs are greater or less than …

There are numerous studies of drug handling in the elderly, but it is difficult to assess the
significance of changes seen in vitro, or after single-dose administration, because they are …

Drug interactions with digoxin are important because of this agent's narrow therapeutic
index. Among the drugs that can decrease digoxin bioavailability are cholestyramine …

The intestinal absorption of digoxin is essentially a passive non-saturable diffusion process,
although a saturable carrier-mediated component also plays an important role. The …

Calcium antagonists are a chemically heterogenous group of agents with potent
cardiovascular effects which are beneficial in the treatment of angina pectoris, arterial …

The antianginal effects of diltiazem and nifedipine alone and in combination were evaluated
in a double-blind, randomized, placebo-controlled trial in 11 patients (nine men and two …

Abstract P-Glycoprotein (P-gp) may have a significant impact on systemic and tissue/cellular
bioavailability of drugs because it functions as an “anti-absorption” mechanism that effluxes …