Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production

F Al‐Habeeb, N Aloufi, H Traboulsi… - Journal of cellular …, 2021 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive scarring caused by excessive
extracellular matrix (ECM) deposition and activation of α‐SMA‐expressing myofibroblasts …

Potential of Mesenchymal Stem Cell-Based Therapies for Pulmonary Fibrosis

Z Guo, Y Zhang, F Yan - DNA and Cell Biology, 2022 - liebertpub.com
Pulmonary fibrosis (PF) is a common pathological feature of acute and chronic inflammatory
lung diseases that currently has no effective clinical treatment. Mesenchymal stem cells …

Increased AGE-RAGE ratio in idiopathic pulmonary fibrosis

C Machahua, A Montes-Worboys, R Llatjos… - Respiratory …, 2016 - Springer
Background The abnormal epithelial-mesenchymal restorative capacity in idiopathic
pulmonary fibrosis (IPF) has been recently associated with an accelerated aging process as …

Fibrocytes in pulmonary fibrosis: a brief synopsis

S Maharaj, C Shimbori, M Kolb - European Respiratory Review, 2013 - Eur Respiratory Soc
Fibrocytes are bone marrow-derived, circulating mesenchymal progenitor cells that play a
role in several fibrotic disorders, including lung fibrosis. They are attracted to injured tissue …

Gentiopicroside ameliorates bleomycin-induced pulmonary fibrosis in mice via inhibiting inflammatory and fibrotic process

C Chen, Y Wang, Y Wang, M Cheng, J Yin… - Biochemical and …, 2018 - Elsevier
Pulmonary fibrosis (PF) is a chronic and ultimately fatal interstitial lung disease of various
causes. The advent of nintedanib and pirfenidone provides treatment options for PF patients …

High-mobility group box 1 mediates epithelial-to-mesenchymal transition in pulmonary fibrosis involving transforming growth factor-β1/Smad2/3 signaling

LC Li, DL Li, L Xu, XT Mo, WH Cui, P Zhao… - … of Pharmacology and …, 2015 - ASPET
Epithelial-to-mesenchymal transition (EMT) is a crucial event in the cellular origin of
myofibroblasts that secrete extracellular matrix in the progression of pulmonary fibrosis (PF) …

Cryptotanshinone reverses the epithelial‐mesenchymal transformation process and attenuates bleomycin‐induced pulmonary fibrosis

Q Zhang, C Gan, H Liu, L Wang, Y Li… - Phytotherapy …, 2020 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a fibrotic interstitial pneumonia that causes pulmonary
tissue damage and functional impairment. To investigate the effects of cryptotanshinone on …

Activating transcription factor 3: A potential therapeutic target for inflammatory pulmonary diseases

D Li, J Jing, X Dong, C Zhang, J Wang… - Immunity, Inflammation …, 2023 - Wiley Online Library
Background Activating transcription factor 3 (ATF3) is a nuclear protein that is widely
expressed in a variety of cells. It is a stress‐inducible transcription gene and a member of …

Association of serum levels of laminin, type IV collagen, procollagen III N-terminal peptide, and hyaluronic acid with the progression of interstitial lung disease

Y Su, H Gu, D Weng, Y Zhou, Q Li, F Zhang, Y Zhang… - Medicine, 2017 - journals.lww.com
Noninvasive and convenient tests to assess pulmonary fibrosis and disease progression in
interstitial lung diseases (ILDs) are currently unavailable. The extracellular matrix molecules …

Regenerative medicine in the treatment of idiopathic pulmonary fibrosis: current position

D Álvarez, M Levine, M Rojas - Stem cells and cloning: advances …, 2015 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible disease of the lung that has
no lasting option for therapy other than transplantation. It is characterized by replacement of …