Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation,
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …

This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …

Nowadays, one of the leading causes of death in humans is cancer, which is still on the rise
globally and is in great need of intense study on the pathogenic mechanism and effective …

Abstract Purpose of Review This review focuses on the concentration of cortisol in human
hair as a biomarker of chronic stress in cardiovascular disease (CVD). We outline the …

The appreciation of human microbiome is gaining strong grounds in biomedical research. In
addition to gut-brain axis, is the lung-brain axis, which is hypothesised to link pulmonary …

Introduction The stress response is different in various individuals, however, the
mechanisms that could explain these distinct effects are not well known and the molecular …

An increasing prevalence of early childhood adversity has reached epidemic proportions,
creating a public health crisis. Rather than focusing only on adverse childhood experiences …

Many studies have consistently demonstrated an epigenetic link between environmental
stimuli and physiological as well as cognitive responses. Epigenetic mechanisms represent …

Depression is associated with alterations in hypothalamic–pituitary–adrenal (HPA) axis
activity. A proposed mechanism to explain these alterations are changes in DNA methylation …

NRF2 is an important regulatory transcription factor involved in tumor immunity and
tumorigenesis. In this study, we firstly identified that FKBP4/NR3C1 axis was a novel …