Magnolol inhibits tumor necrosis factor-α-induced ICAM-1 expression via suppressing NF-κB and MAPK signaling pathways in human lung epithelial cells

W Chunlian, W Heyong, X Jia, H Jie, C Xi, L Gentao - Inflammation, 2014 - Springer
Magnolol is a traditional Chinese medicine from the root and bark of Magnolia officinalis. It
has long been used to treat anxiety, cough, headache and allergies, as well as a variety of …

Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice

DH Kuo, YS Lai, CY Lo, AC Cheng, H Wu… - Journal of Agricultural …, 2010 - ACS Publications
Magnolol has been reported to have an anti-inflammatory and antitumor effect in vitro and in
vivo. Herein, we report the investigation of the inhibitory effects of magnolol on 12-O …

BACE-1 Inhibitors Targeting Alzheimer's Disease

KL Chagas Monteiro… - Current Alzheimer …, 2023 - ingentaconnect.com
The accumulation of amyloid-β (Aβ) is the main event related to Alzheimer's disease (AD)
progression. Over the years, several disease-modulating approaches have been reported …

Natural Polyphenols—Resveratrol, Quercetin, Magnolol, and β-Catechin—Block Certain Aspects of Heroin Addiction and Modulate Striatal IL-6 and TNF-α

S ElShebiney, R Elgohary, M El-Shamarka, N Mowaad… - Toxics, 2023 - mdpi.com
We have examined the effects of four different polyphenols in attenuating heroin addiction
using a conditioned place preference (CPP) paradigm. Adult male Sprague Dawley rats …

Identification of Magnolia officinalis L. Bark Extract as the Most Potent Anti-Inflammatory of Four Plant Extracts

JM Walker, A Maitra, J Walker… - The American journal …, 2013 - World Scientific
This study was designed to compare the anti-inflammatory potential of a Magnolia officinalis
L. bark extract solely or in combination with extracts prepared from either Polygonum …

Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells

TC Chuang, SC Hsu, YT Cheng, WS Shao, K Wu… - Cancer letters, 2011 - Elsevier
Overexpression of the HER2 oncogene contributes to tumor cell invasion, metastasis and
angiogenesis and correlates with poor prognosis. Magnolol has been reported to exhibit anti …

[HTML][HTML] Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to …

D Piasecka, M Braun, M Mieszkowska, L Kowalczyk… - Neoplasia, 2020 - Elsevier
There are data to suggest that some ductal carcinoma in situ (DCIS) may evolve through an
evolutionary bottleneck, where minor clones susceptible to the imposed selective pressure …

Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model

JH Wang, KS Shih, JP Liou, YW Wu, ASY Chang… - PLoS …, 2012 - journals.plos.org
Fibroblast-like synoviocytes (FLS) play an important role in the pathologic processes of
destructive arthritis by producing a number of catabolic cytokines and metalloproteinases …

Comparative inhibitory effects of magnolol, honokiol, eugenol and bis-eugenol on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264. 7 …

Y Murakami, A Kawata, Y Seki, T Koh, K Yuhara… - In Vivo, 2012 - iv.iiarjournals.org
Background: The anti-inflammatory activity of magnolol and related compounds is currently
a focus of interest. In the present study, the inhibitory effects of these compounds on …

Limonoids from the fruits of Melia toosendan and their NF-κB modulating activities

GY Zhu, LP Bai, L Liu, ZH Jiang - Phytochemistry, 2014 - Elsevier
Eight ring C-seco and ring-intact limonoids, and 25 known limonoids were isolated from the
fruits of Melia toosendan (Meliaceae). Their structures were elucidated on the basis of …