A novel prognostic index of stomach adenocarcinoma based on immunogenomic landscape analysis and immunotherapy options

W Xue, B Dong, Y Wang, Y Xie, P Li, Z Gong… - … and Molecular Pathology, 2022 - Elsevier
Stomach adenocarcinoma (STAD) is one of the most common malignant tumors worldwide.
In this study, we attempted to construct a valid immune-associated gene prognostic index …

Implications of intratumor heterogeneity on consensus molecular subtype (CMS) in colorectal cancer

S Chowdhury, M Hofree, K Lin, D Maru, S Kopetz… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer (CRC) has been divided into four consensus molecular
subtypes (CMS) using the unsupervised clustering of bulk transcriptomic data. The CMS …

The KRAS-Mutant Consensus Molecular Subtype 3 Reveals an Immunosuppressive Tumor Microenvironment in Colorectal Cancer

P Tanjak, A Chaiboonchoe, T Suwatthanarak… - Cancers, 2023 - mdpi.com
Simple Summary The poor prognosis outcome of patients with KRAS mutations (KRAS mut)
was correlated with an immunosuppressive tumor microenvironment (TME). At the gene …

[HTML][HTML] Macrophages, as a promising strategy to targeted treatment for colorectal cancer metastasis in tumor immune microenvironment

Y Zhang, Y Zhao, Q Li, Y Wang - Frontiers in Immunology, 2021 - frontiersin.org
The tumor immune microenvironment plays a vital role in the metastasis of colorectal cancer.
As one of the most important immune cells, macrophages act as phagocytes, patrol the …

Immune landscape refines the classification of colorectal cancer with heterogeneous prognosis, tumor microenvironment and distinct sensitivity to frontline therapies

Z Liu, Y Guo, X Yang, C Chen, D Fan, X Wu… - Frontiers in Cell and …, 2022 - frontiersin.org
The immune microenvironment has profound impacts on the initiation and progression of
colorectal cancer (CRC). Therefore, the goal of this article is to identify two robust immune …

[HTML][HTML] M6A “Writer” Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer

C Cai, J Long, Q Huang, Y Han, Y Peng, C Guo… - Frontiers in …, 2021 - frontiersin.org
Rectal cancer (RC) is the leading cause of tumor-related death among both men and
women. The efficacy of immunotherapy for rectal cancer is closely related to the immune …

Sintilimab plus bevacizumab and CapeOx (BBCAPX) on first-line treatment in patients with RAS mutant, microsatellite stable, metastatic colorectal cancer: study …

X Fang, C Zhong, S Weng, H Hu, J Wang, Q Xiao… - BMC cancer, 2023 - Springer
Background Rat sarcoma viral oncogene homolog (RAS) gene mutation is a common
molecular event in colorectal cancer (CRC). The prognosis of mCRC (metastatic colorectal …

[HTML][HTML] Role of macrophages in progression of colorectal cancer: a contrast with the traditional paradigm

AS Konstantinov, OV Kovaleva… - … Journal of Clinical …, 2022 - ncbi.nlm.nih.gov
The phenotype of tumor-associated macrophages may be critical for tumor immunity,
angiogenesis, and clinical disease outcome. Here, we elucidated the prognostic …

Combinatorial immunotherapies for metastatic colorectal cancer

E Janssen, B Subtil, F de la Jara Ortiz, HMW Verheul… - Cancers, 2020 - mdpi.com
Colorectal cancer (CRC) is one of the most frequent and deadly forms of cancer. About half
of patients are affected by metastasis, with the cancer spreading to eg, liver, lungs or the …

Immunotherapy in colorectal cancer

P Agarwal, DT Le, PM Boland - Advances in Cancer Research, 2021 - Elsevier
The immune tumor microenvironment (TME) of colorectal cancer (CRC) is a crucial
contributor to disease biology, making it an important target for therapeutic intervention. The …