Pseudomonas (P.) aeruginosa is an opportunistic pathogen that causes serious infections
and hospital-acquired pneumonia in immunocompromised patients. P. aeruginosa accounts …

Pulmonary fibrosis (PF) is a progressive chronic lung disease characterized by excessive
deposition of extracellular matrix (ECM) and structural destruction, associated with a severe …

Patients with ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) are often
septic and with poor prognosis, which leads to a high mortality rate of 25–40%. Despite the …

Background Acute lung injury (ALI) is a life-threatening condition that fundamentally results
from inflammation and edema in the lung. There are no effective treatments available for …

Acute lung injury (ALI) represents a life-threatening condition with high morbidity and
mortality despite modern mechanical ventilators and multiple pharmacological strategies …

Barrier dysfunction is the hallmark of severe lung injury, including acute respiratory distress
syndrome. Efficient medical countermeasures to counteract endothelial hyperpermeability …

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are characterized by
pulmonary microvascular endothelial cells (PMVECs) barrier dysfunction and …

Sphingolipids are bioactive lipids involved in the regulation of cell survival, proliferation, and
the inflammatory response. The SphK/S1P/S1PR pathway (S1P pathway) is a driver of many …

In acute lung injury (ALI), the NF-κB-mediated downregulation of Sox18 gene expression
leads to the disruption of the pulmonary endothelial barrier. Previous studies have …

COVID-19 has been shown to induce neuroinflammation and CNS manifestations. A swift
and efficient treatment strategy is urgently warranted for the management of COVID …