Abstract Individuals with 5α-reductase-2 deficiency (5α-RD-2) and 17β-hydroxysteroid
dehydrogenase-3 deficiency (17β-HSD-3) are often raised as girls. Over the past number of …

Traditional permeability studies of full-thickness skin have implied molecules permeated
through the skin by various polar or nonpolar pathways depending on the hydrophilicity or …

Sexual differentiation is the result of complex genetic and endocrine mechanisms that are
closely associated with the development of both the genitourinary system and the adrenal …

Sixty-eight males with testicular 17β-hydroxysteroid dehydrogenase deficiency (17β-HSD)
were identified among a highly inbred Arab population in Israel, and 45 studied over the last …

The successful introduction of nitroglycerin transdermal delivery systems for the prophylactic
treatment of angina pectoris has spawned an explosion of interest in this route of drug …

Background 17β-Hydroxysteroid dehydrogenase type-3 (17βHSD-3) deficiency is a rare
cause of 46, XY disorders of sex development. The enzyme converts androstenedione to …

We studied an 18-year-old woman with progressive hirsutism, secondary amenorrhea, and
polycystic ovarian disease. Excess androstenedione was secreted by the ovaries, most …

Three sisters with male pseudohermaphroditism due to 17β‐hydroxysteroid dehydrogenase
deficiency are described. On the basis of a 46 XY karyotype and female phenotype all …

Studies in six Arab individuals from Gaza with familial male pseudohermaphroditism (MPH)
due to 17-ketoreductase deficiency revealed several metabolic aberrations associated with …

A 46. XY phenotypically male patient with 17-ketosteroid reductase deficiency is described.
The patient was a 6-month-old infant who presented with rhicropenis and bilateral …