Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration

DJ Hellenbrand, CM Quinn, ZJ Piper… - Journal of …, 2021 - Springer
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …

Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy

F Cofano, M Boido, M Monticelli, F Zenga… - International journal of …, 2019 - mdpi.com
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial
phase in the pathophysiological process of SCI concerns the well-known secondary injury …

Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury

T Zrzavy, C Schwaiger, I Wimmer, T Berger, J Bauer… - Brain, 2021 - academic.oup.com
Traumatic spinal cord injury is a devastating insult followed by progressive cord atrophy and
neurodegeneration. Dysregulated or non-resolving inflammatory processes can disturb …

Current options for cell therapy in spinal cord injury

I Vismara, S Papa, F Rossi, G Forloni… - Trends in molecular …, 2017 - cell.com
Spinal cord injury (SCI) is a complex pathology that evolves after primary acute mechanical
injury, causing further damage to the spinal cord tissue that exacerbates clinical outcomes …

Macrophage polarization: a key event in the secondary phase of acute spinal cord injury

X Kong, J Gao - Journal of cellular and molecular medicine, 2017 - Wiley Online Library
Acute spinal cord injury (SCI) has become epidemic in modern society. Despite advances
made in the understanding of the pathogenesis and improvements in early recognition and …

IL‐4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury

I Francos‐Quijorna, J Amo‐Aparicio… - Glia, 2016 - Wiley Online Library
Macrophages and microglia play a key role in the maintenance of nervous system
homeostasis. However, upon different challenges, they can adopt several phenotypes …

Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation

C Wang, Q Wang, Y Lou, J Xu, Z Feng… - Journal of cellular …, 2018 - Wiley Online Library
Spinal cord injury (SCI) is a severe neurological disease; however, few drugs have been
proved to treat SCI effectively. Neuroinflammation is the major pathogenesis of SCI …

[HTML][HTML] Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury

F Gong, T Ge, J Liu, J Xiao, X Wu, H Wang… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) is the main cause of severe damage to the central nervous system
and leads to irreversible tissue loss and neurological dysfunction. Ferroptosis is a cell death …

Maresin 1 promotes inflammatory resolution, neuroprotection, and functional neurological recovery after spinal cord injury

I Francos-Quijorna, E Santos-Nogueira… - Journal of …, 2017 - Soc Neuroscience
Resolution of inflammation is defective after spinal cord injury (SCI), which impairs tissue
integrity and remodeling and leads to functional deficits. Effective pharmacological …

Stem cells therapy for spinal cord injury

M Gazdic, V Volarevic, CR Harrell… - International journal of …, 2018 - mdpi.com
Spinal cord injury (SCI), a serious public health issue, most likely occurs in previously
healthy young adults. Current therapeutic strategies for SCI includes surgical …