Uric acid in health and disease: From physiological function to pathogenic mechanism

S Wen, H Arakawa, I Tamai - Pharmacology & Therapeutics, 2024 - Elsevier
Owing to renal reabsorption and the loss of uricase activity, uric acid (UA) is strictly
maintained at a higher physiological level in humans than in other mammals, which …

Association between weight-adjusted-waist index and the risk of hyperuricemia in adults: a population-based investigation

Y Ding, Z Xu, X Zhou, Y Luo, R Xie, Y Li - Frontiers in Endocrinology, 2023 - frontiersin.org
Objective This investigation sought to elucidate the potential correlation between a recently
characterized adiposity metric, termed the Weight-Adjusted-Waist Index (WWI) and …

Increased risk of chronic kidney disease in uric acid stone formers with high neutrophil-to-lymphocyte ratio

HT Tung, CM Liu, HS Huang, ZH Lu, CJ Liu - Scientific reports, 2023 - nature.com
Urolithiasis is associated with an increased risk of chronic kidney disease (CKD),
irrespective of stone compositions. Chronic inflammation is an important factor for CKD …

9-Hydroxy-8-oxypalmatine, a novel liver-mediated oxymetabolite of palmatine, alleviates hyperuricemia and kidney inflammation in hyperuricemic mice

X Wu, R Huang, G Ai, H Chen, X Ma, J Zhang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Palmatine is a main bioactive alkaloid of Cortex
Phellodendri, which has been commonly prescribed for the treatment of hyperuricemia …

Association of urinary excretion rates of uric acid with biomarkers of kidney injury in patients with advanced chronic kidney disease

A López Iglesias, M Blanco Pardo… - Plos one, 2024 - journals.plos.org
Background The potential influence of hyperuricemia on the genesis and progression of
chronic kidney disease (CKD) remains controversial. In general, the correlation between …

Using intravoxel incoherent motion imaging to evaluate uric acid-induced renal injury and efficacy after treatment

ZY Cheng, SA Gong, PK Chen, ZC Yu… - British Journal of …, 2024 - academic.oup.com
Objectives To validate the feasibility of intravoxel incoherent motion imaging (IVIM) for
monitoring renal injury and uric acid-lowering efficacy in a rat model of hyperuricaemia …

The pathogenic mechanism of monosodium urate crystal-induced kidney injury in a rat model

D Li, Y Li, X Chen, J Ouyang, D Lin, Q Wu… - Frontiers in …, 2024 - frontiersin.org
Objective (MSU) crystals usually in the kidney tubules especially collecting ducts in the
medulla. Previous animal models have not fully reproduced the impact of MSU on kidneys …

Optical real-time cardiorenal toxin uric acid measurement during hemodialysis using a miniaturized optical sensor

J Holmar, J Arund, A Adoberg, L Leis… - 2023 45th Annual …, 2023 - ieeexplore.ieee.org
Patients with chronic kidney disease (CKD) are at higher cardiovascular risk than the
general population. Cardiovascular diseases, vascular calcification among them, are the …

Prediction of acute kidney injury after coronary artery bypass graft from preoperative serum uric acid

C Huang, J Qiu, XM Fang - Journal of Cardiothoracic and Vascular …, 2024 - Elsevier
Objective Acute kidney injury (AKI) frequently occurs during coronary artery bypass graft
(CABG) procedures and poses challenges in terms of prognostication. This study aimed to …

Безсимптомна і симптомна гіперурикемія: інноваційна стратегія лікування

С Кушніренко, Л Савицька… - Сімейна …, 2023 - family-medicine.com.ua
Анотація Безсимптомна гіперурикемія асоціюється з безліччю соматичних
захворювань, виникненням і прогресуванням хронічної хвороби нирок (ХХН), зі …