The essential role of B cells is to produce protective immunoglobulins (Ig) that recognize,
neutralize, and clear invading pathogens. This results from the integration of signals …

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M.
tuberculosis). In lymphopenia, T cells are typically characterized by progressive loss and a …

Chemokine receptors are members of the G protein–coupled receptor superfamily. The CXC
chemokine receptor type 4 (CXCR4), one of the most studied chemokine receptors, is widely …

It is well known how sequencing technologies propelled cellular biology research in recent
years, providing incredible insight into the basic mechanisms of cells. Single-cell RNA …

Leukemic B-cells are lodged in the bone marrow [BM], a complex organ composed of many
cell types and extracellular matrix. Determining how the reciprocal interactions between …

Hematopoietic stem cell transplantation has been the standard of care for infants with severe
combined immunodeficiency (SCID) since 1968, and although the requirement for …

It is well-known how sequencing technologies propelled cellular biology research in recent
years, giving an incredible insight into the basic mechanisms of cells. Single-cell RNA …

Detailed knowledge of the human B-cell development is crucial for proper interpretation of
inborn errors of immunity and for malignant diseases. It is of interest to understand the …

The field of regenerative medicine and bioengineering presents an exciting opportunity to
harness the potential of hematopoietic stem cells (HSCs) through stem cell niche and …

Follicular Lymphoma (FL) is an indolent type of Non-Hodgkin's Lymphoma comprising 20%
of new lymphoma diagnosis with a risk of transforming into a more aggressive B-cell …