ABSTRACT GR135402, a sordarin derivative, was isolated in an antifungal screening
program. GR135402, sordarin, and derivatives of both compounds were evaluated for their …

The need for new drugs to treat systemic fungal infections has intensified due to the rapid
growth of the immunocompromised patient population. 1 The increase in the frequency of …

Carbohydrate–receptor interactions are often involved in the docking of viruses to host cells,
and this docking is a necessary step in the virus life cycle that precedes infection and …

Materials and Methods Chemicals UDP-glucose[glucose-14C] and UDP-N-acetyl-
glucosamine [glucosamine-14C] were obtained from New England Nuclear (Boston, MA) …

Despite the development of newer antifungal drugs, the polyene antifungals continue to be
the most potent broad-spectrum fungicides available for clinical use. The incidence and …

A series of novel aza-d--homosteroids and their hydroisoquinoline precursors were
synthesized and tested for antifungal activity against a variety of a strain strains and also s …

Compound 1 is a macrocyclic lipopeptide belonging to the echinocandin family, which has
been effective in treating systemic fungal infections. In this paper, we report a unique regio …

Amphotericin B (AmB) has been widely used in antifungal therapy. AmB molecules combine
with cholesterol to form pores that can be toxic to human cells, thus greatly limiting its clinical …

Myzellare Pilze und Hefen sind schon lange bekannt-beim Einsatz im Back-und
Braugewerbe. In den letzten beiden Jahrzehnten nahm jedoch ihre Bedeutung für andere …

Interaction between AmB and cell membrane is influenced by different metal cations. In the
presence of K+, Na+ or Ca 2+ ions, the surface pressure-area isotherms and the elastic …