Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
PA Reyfman, JM Walter, N Joshi… - American journal of …, 2019 - atsjournals.org
Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
Unraveling the interplay between vital organelle stress and oxidative stress in idiopathic pulmonary fibrosis
A Mohanan, KR Washimkar, MN Mugale - Biochimica et Biophysica Acta …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized
by excessive accumulation of extracellular matrix, leading to irreversible fibrosis. Emerging …
by excessive accumulation of extracellular matrix, leading to irreversible fibrosis. Emerging …
Effect of continued treatment with pirfenidone following clinically meaningful declines in forced vital capacity: analysis of data from three phase 3 trials in patients with …
Background The assessment of treatment response in idiopathic pulmonary fibrosis (IPF) is
complicated by the variable clinical course. We examined the variability in the rate of …
complicated by the variable clinical course. We examined the variability in the rate of …
Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression
G Yang, L Yang, W Wang, J Wang, J Wang, Z Xu - Gene, 2015 - Elsevier
Background Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease
of unknown etiology that is currently untreatable. In this study we aim to characterize the …
of unknown etiology that is currently untreatable. In this study we aim to characterize the …
The future of the development of medicines in idiopathic pulmonary fibrosis
L Fregonese, I Eichler - BMC medicine, 2015 - Springer
The development of treatments for idiopathic pulmonary fibrosis (IPF) has been often
disappointing. Building on authorized treatments that can benchmark the validity of …
disappointing. Building on authorized treatments that can benchmark the validity of …
Single-cell transcriptomic analysis of human lung reveals complex multicellular changes during pulmonary fibrosis
PA Reyfman, JM Walter, N Joshi, KR Anekalla… - BioRxiv, 2018 - biorxiv.org
Pulmonary fibrosis is a devastating disorder that results in the progressive replacement of
normal lung tissue with fibrotic scar. Available therapies slow disease progression, but most …
normal lung tissue with fibrotic scar. Available therapies slow disease progression, but most …
Targeting N4BP2L1 for Therapy in IPF and SSc-ILD: Evidence from Mendelian Randomization and Multi-Omics Analysis
X Lv, W Tang, S Ou, F Yang, W Wang… - Available at SSRN …, 2024 - papers.ssrn.com
Background: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) and idiopathic
pulmonary fibrosis (IPF) are paradigmatic conditions characterized by similar pathogenic …
pulmonary fibrosis (IPF) are paradigmatic conditions characterized by similar pathogenic …
益气养阴方对肺间质纤维化大鼠肺组织TNF-α, TGF-β1 和IFN-γ mRNA 水平的影响
蔡杰， 谭利平， 冯佳， 刘冬梅， 赵小丹， 夏燕， 袁林… - 细胞与分子免疫学 …, 2015 - cqvip.com
目的观察益气养阴方对大鼠肺间质纤维化模型肺组织形态结构及肿瘤坏死因子仅(TNF-α),
转化生长因子13 (TGF-131), γ 干扰素(IFN-γ) mRNA 水平的影响. 方法通过气管内滴注博莱霉素 …
转化生长因子13 (TGF-131), γ 干扰素(IFN-γ) mRNA 水平的影响. 方法通过气管内滴注博莱霉素 …
[PDF][PDF] 通络益气方对博来霉素致大鼠肺纤维化的治疗作用研究
蒋鹏娜， 张莹莹， 江柏华， 张佩青… - Progress in Modern …, 2022 - biomed.cnjournals.com
摘要目的: 研究通络益气方对博来霉素致大鼠模型肺组织病理及肺组织羟脯氨酸(HYP) 的影响.
方法: 将36 只SPF 级健康6 周龄Wistar 雄性大鼠置于SPF 级条件下, 适应性试养3 天后, 分为3 …
方法: 将36 只SPF 级健康6 周龄Wistar 雄性大鼠置于SPF 级条件下, 适应性试养3 天后, 分为3 …
槲皮素对大鼠肺纤维化抑制作用的研究
谢鹏， 赵洪梅 - 解放军医药杂志, 2014 - cqvip.com
目的: 探讨槲皮素在大鼠肺纤维化过程中的作用及机制. 方法选择健康Wistar 大鼠63 只,
随机均分为7 组: 对照组, 模型组2 周(A2 组), 模型组4 周(A4 组), 模型组6 周(A6 组), 槲皮素组2 …
随机均分为7 组: 对照组, 模型组2 周(A2 组), 模型组4 周(A4 组), 模型组6 周(A6 组), 槲皮素组2 …