[HTML][HTML] The immune epitope database and analysis resource in epitope discovery and synthetic vaccine design
The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics
analytic tools and access to depositories of curated data relevant to immune reactions and …
analytic tools and access to depositories of curated data relevant to immune reactions and …
T cell epitope predictions
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
Gapped sequence alignment using artificial neural networks: application to the MHC class I system
M Andreatta, M Nielsen - Bioinformatics, 2016 - academic.oup.com
Motivation: Many biological processes are guided by receptor interactions with linear
ligands of variable length. One such receptor is the MHC class I molecule. The length …
ligands of variable length. One such receptor is the MHC class I molecule. The length …
[HTML][HTML] Properties of MHC class I presented peptides that enhance immunogenicity
JJA Calis, M Maybeno, JA Greenbaum… - PLoS computational …, 2013 - journals.plos.org
T-cells have to recognize peptides presented on MHC molecules to be activated and elicit
their effector functions. Several studies demonstrate that some peptides are more …
their effector functions. Several studies demonstrate that some peptides are more …
Computational genomics tools for dissecting tumour–immune cell interactions
Recent breakthroughs in cancer immunotherapy and decreasing costs of high-throughput
technologies have sparked intensive research into tumour–immune cell interactions using …
technologies have sparked intensive research into tumour–immune cell interactions using …
[HTML][HTML] Peptide binding predictions for HLA DR, DP and DQ molecules
Background MHC class II binding predictions are widely used to identify epitope candidates
in infectious agents, allergens, cancer and autoantigens. The vast majority of prediction …
in infectious agents, allergens, cancer and autoantigens. The vast majority of prediction …
Contextual gaussian process bandit optimization
How should we design experiments to maximize performance of a complex system, taking
into account uncontrollable environmental conditions? How should we select relevant …
into account uncontrollable environmental conditions? How should we select relevant …
[HTML][HTML] Reverse vaccinology: developing vaccines in the era of genomics
A Sette, R Rappuoli - Immunity, 2010 - cell.com
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
[HTML][HTML] Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction
Abstract Background Reliable predictions of Cytotoxic T lymphocyte (CTL) epitopes are
essential for rational vaccine design. Most importantly, they can minimize the experimental …
essential for rational vaccine design. Most importantly, they can minimize the experimental …
[HTML][HTML] More than one reason to rethink the use of peptides in vaccine design
The use of peptides as therapeutics is experiencing renewed enthusiasm owing to
advances in delivery, stability and design. Moreover, there is a growing emphasis on the use …
advances in delivery, stability and design. Moreover, there is a growing emphasis on the use …