Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …

Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …

Cancer immunoediting is the process whereby the immune system suppresses neoplastic
growth and shapes tumor immunogenicity. We previously reported that type I interferon (IFN …

Outbreaks of severe virus infections with the potential to cause global pandemics are
increasing. In many instances these outbreaks have been newly emerging (SARS …

Significantly higher levels of plasma CXCL13 [chemokine (CXC motif) ligand 13] were
associated with the generation of broadly neutralizing antibodies (bnAbs) against HIV in a …

CD8+ T cells may play a dual role in protection against and pathogenesis of flaviviruses,
including Zika virus (ZIKV). We evaluated the CD8+ T cell response in ZIKV-infected …

CD8 T cells require a third signal, along with Ag and costimulation, to make a productive
response and avoid death and/or tolerance induction. Recent studies indicate that IL-12 and …

Abstract Type I interferons (IFN-I) are well-known inducers of tumor cell apoptosis and
antiangiogenesis via signaling through a common receptor interferon alpha receptor …

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis
factor receptor/tumor necrosis factor superfamily and are expressed on activated CD4+ and …