Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the
uses of these compounds are disclosed, together with the use, eg to treat a condition …

I. Abstract The remarkable structure, biosynthesis, cell biology, and membrane biology of
glycosylphosphatidylinositol (GPI) anchors of cell surface proteins have generated …

5,001,064 A 3/1991 Deuel................ 435/194 (57) ABSTRACT 5,100,787 A 3/1992 Shimizu
et al.... 435,131 One aspect of the present invention relates to solution-phase 5,214,180 A 5 …

Carbohydrate chemists have been remarkably successful at developing methods for the
chemical synthesis of glycosylphosphatidylinositols (GPIs), a highly complex and structurally …

We have developed an efficient synthetic strategy to HexNH2‐α (1⇄ 3)‐l‐chiro‐inositol (XII−
XIII) and HexNH2‐α (1⇄ 2)‐d‐chiro‐inositol (XIV− XV) based on the regio and …

Trypanosoma cruzi is a protozoan, responsible for Chagas disease, that parasites
triatomines and some vertebrates, mainly Homo sapiens. In 2010, nearly 10 million people …

Though insulin signalling is thought by many groups to function without second messenger
action, others have provided evidence for the existence and action of such regulators …

The influence of protecting groups on the reactivity of glycosyl acceptors has been
investigated through a series of competitive glycosylation experiments using differently …

A new solid system based on montmorillonite supported oxone has been developed and
used for the oxidation of thiomannoside. The oxidation properties of oxone immobilized on …

One aspect of the present invention relates to solution-phase approaches to GPI synthesis.
Another aspect of the present invention relates to key building blocks, and syntheses …