Chemistry, structure and function of approved oligonucleotide therapeutics
M Egli, M Manoharan - Nucleic Acids Research, 2023 - academic.oup.com
Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …
Advances in targeting 'undruggable'transcription factors with small molecules
MJ Henley, AN Koehler - Nature Reviews Drug Discovery, 2021 - nature.com
Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
[HTML][HTML] CRISPR–Cas9 structures and mechanisms
Many bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–
CRISPR-associated (Cas) systems employ the dual RNA–guided DNA endonuclease Cas9 …
CRISPR-associated (Cas) systems employ the dual RNA–guided DNA endonuclease Cas9 …
Double-stranded RNA sensors and modulators in innate immunity
S Hur - Annual review of immunology, 2019 - annualreviews.org
Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …
defense in many organisms. We here discuss several families of dsRNA-binding proteins …
Predicting the sequence specificities of DNA-and RNA-binding proteins by deep learning
Knowing the sequence specificities of DNA-and RNA-binding proteins is essential for
developing models of the regulatory processes in biological systems and for identifying …
developing models of the regulatory processes in biological systems and for identifying …
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
The CRISPR-associated enzyme Cas9 is an RNA-guided endonuclease that uses RNA:
DNA base-pairing to target and cleave foreign DNA as part of an adaptive immune system in …
DNA base-pairing to target and cleave foreign DNA as part of an adaptive immune system in …
DNA-dependent formation of transcription factor pairs alters their binding specificity
Gene expression is regulated by transcription factors (TFs), proteins that recognize short
DNA sequence motifs,,. Such sequences are very common in the human genome, and an …
DNA sequence motifs,,. Such sequences are very common in the human genome, and an …
Transcription factor–DNA binding: beyond binding site motifs
S Inukai, KH Kock, ML Bulyk - Current opinion in genetics & development, 2017 - Elsevier
Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …
[HTML][HTML] Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
[HTML][HTML] The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress
Cellular homeostasis is coordinated through communication between mitochondria and the
nucleus, organelles that each possess their own genomes. Whereas the mitochondrial …
nucleus, organelles that each possess their own genomes. Whereas the mitochondrial …