Biological tissues require oxygen to meet their energetic demands. However, the
consumption of oxygen also results in the generation of free radicals that may have …

Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …

This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …

Within the last twenty years the view on reactive oxygen species (ROS) has changed; they
are no longer only considered to be harmful but also necessary for cellular communication …

Stroke and circulatory arrest cause interferences in blood flow to the brain that result in
considerable tissue damage. The primary method to reduce or prevent neurologic damage …

The selective removal of undesired or damaged mitochondria by autophagy, known as
mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion …

Cerebral ischemia/reperfusion injury activates microglia, resident immune cells in the brain,
and allows the infiltration of circulating immune cells into the ischemic lesions. Microglia play …

Stroke is one of the leading causes of mortality and morbidity, with astronomical financial
repercussions on health systems worldwide. Ischaemic stroke accounts for approximately 80 …

Significant amounts of oxygen free radicals (oxidants) are generated during cerebral
ischemia/reperfusion, and oxidative stress plays an important role in brain damage after …

Cancer treatments are increasingly effective, but can result in iatrogenic premature ovarian
insufficiency. Ovarian tissue cryopreservation is the only option available to preserve fertility …