After cell-to-cell transmission, HTLV-I increases its viral genome by de novo infection and
proliferation of infected cells. Proliferation of infected cells is clonal and persistent in vivo …

Human T-cell lymphotropic virus type 1 (HTLV-1) has been identified as the causative agent
of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic …

Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia
(ATL), a rapidly progressing, clonal malignancy of CD4+ T lymphocytes. Fewer than one in …

Abstract HTLV-1 and HTLV-2 are highly related complex retroviruses that have been studied
intensely for nearly three decades because of their association with neoplasia …

Human T lymphotropic viruses (HTLVs) are complex deltaretroviruses that do not contain a
proto-oncogene in their genome, yet are capable of transforming primary T lymphocytes …

Recognition and repair of DNA damage is critical for maintaining genomic integrity and
suppressing tumorigenesis. In eukaryotic cells, the sensing and repair of DNA damage are …

The cAMP response element‐binding protein (CREB) is a stimulus‐induced transcription
factor that responds rapidly to phosphorylation and/or coactivator activation. Regulated …

Human T-lymphotropic virus type 1 (HTLV-1) is a persistent CD4+ T-lymphotropic retrovirus.
Most HTLV-1-infected individuals remain asymptomatic, but a proportion develop adult T cell …

The acquisition of a cancerous phenotype by epithelial cells involves the disruption of
intercellular adhesions. The reorganization of the E-cadherin/β-catenin complex in adherens …

The transcription factor NF-κB is critical for the induction of cancer, including adult T-cell
leukemia, which is linked to infection by human T-cell leukemia virus type 1 and the …