Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan
The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …
disease caused by tobacco smoking in genetically susceptible individuals has been …
[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
[HTML][HTML] Neuroscience of trauma and the Russian invasion of Ukraine
To the editor—The neuroscience of trauma informs us that the Russian invasion of Ukraine
may have alarming implications for global mental health, affecting not only Ukrainian but …
may have alarming implications for global mental health, affecting not only Ukrainian but …
Sex differences in the intergenerational inheritance of metabolic traits
I Sandovici, DS Fernandez-Twinn, A Hufnagel… - Nature …, 2022 - nature.com
Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …
including those in utero, influence our long-term metabolic health. This has been termed …
[HTML][HTML] Biological embedding of early-life adversity and a scoping review of the evidence for intergenerational epigenetic transmission of stress and trauma in …
Severe or chronic stress and trauma can have a detrimental impact on health. Evidence
suggests that early-life adversity can become biologically embedded and has the potential …
suggests that early-life adversity can become biologically embedded and has the potential …
[HTML][HTML] Mechanisms by which adverse childhood experiences, other traumas and PTSD influence the health and well-being of individuals with eating disorders …
TD Brewerton - Journal of eating disorders, 2022 - Springer
Background Multiple published sources from around the world have confirmed an
association between an array of adverse childhood experiences (ACEs) and other traumatic …
association between an array of adverse childhood experiences (ACEs) and other traumatic …
Epigenetic transgenerational inheritance, gametogenesis and germline development†
M Ben Maamar, EE Nilsson… - Biology of …, 2021 - academic.oup.com
One of the most important developing cell types in any biological system is the gamete
(sperm and egg). The transmission of phenotypes and optimally adapted physiology to …
(sperm and egg). The transmission of phenotypes and optimally adapted physiology to …
[HTML][HTML] Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice
Transmission of epigenetic information between generations occurs in nematodes, flies and
plants, mediated by specialised small RNA pathways, modified histones and DNA …
plants, mediated by specialised small RNA pathways, modified histones and DNA …
[HTML][HTML] Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: a call for research on developmental programming
V Gaillard, S Chastant, G England, O Forman… - Frontiers in Veterinary …, 2022 - frontiersin.org
Many dogs and cats are affected by chronic diseases that significantly impact their health
and welfare and relationships with humans. Some of these diseases can be challenging to …
and welfare and relationships with humans. Some of these diseases can be challenging to …
Preconception origins of asthma, allergies and lung function: the influence of previous generations on the respiratory health of our children
C Svanes, JW Holloway… - Journal of Internal …, 2023 - Wiley Online Library
Emerging research suggests that exposures occurring years before conception are
important determinants of the health of future offspring and subsequent generations …
important determinants of the health of future offspring and subsequent generations …