Neonates, infants, and children differ from adults in many aspects, not just in age, weight,
and body composition. Growth, maturation and environmental factors affect drug kinetics …

A majority of therapeutics are not available as suitable dosage forms for administration to
pediatric patients. The first part of this review provides an overview of clinical and …

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Knowledge about the safe and effective use of medicines in neonates has increased
substantially but has resulted in few label changes. Drugs developed for use in adults are …

Paediatric patients, particularly preterm neonates, present many pharmacological
challenges. Due to the difficulty in conducting clinical trials in these populations dosing …

Background Population pharmacokinetic evaluations have been widely used in neonatal
pharmacokinetic studies, while machine learning has become a popular approach to solving …

A thorough knowledge of the newborn (age, birth to 1 month postpartum) infant's
gastrointestinal tract (GIT) is critical to the evaluation of the absorption, distribution …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …

The development of age-appropriate formulations should focus on dosage forms that can
deliver variable yet accurate doses that are safe and acceptable to the child, are matched to …

Therapeutic drug monitoring (TDM) should be adopted in all neonatal intensive care units
(NICUs), where the most preterm and fragile babies are hospitalized and treated with many …