Medical micro/nanorobots in precision medicine

F Soto, J Wang, R Ahmed, U Demirci - Advanced science, 2020 - Wiley Online Library
Advances in medical robots promise to improve modern medicine and the quality of life.
Miniaturization of these robotic platforms has led to numerous applications that leverages …

3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate

J Nicolas, S Magli, L Rabbachin, S Sampaolesi… - …, 2020 - ACS Publications
Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

Dynamic covalent hydrogels as biomaterials to mimic the viscoelasticity of soft tissues

S Tang, BM Richardson, KS Anseth - Progress in Materials Science, 2021 - Elsevier
The extracellular matrix (ECM) and its mechanical properties play an important role in
regulating the cellular responses that occur during tissue regeneration, wound healing, and …

Rolling circle amplification (RCA)-based DNA hydrogel

C Yao, R Zhang, J Tang, D Yang - Nature protocols, 2021 - nature.com
DNA hydrogels have unique properties, including sequence programmability, precise
molecular recognition, stimuli-responsiveness, biocompatibility and biodegradability, that …

Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction

W Xie, X Wei, H Kang, H Jiang, Z Chu, Y Lin… - Advanced …, 2023 - Wiley Online Library
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Surface roughness gradients reveal topography‐specific mechanosensitive responses in human mesenchymal stem cells

Y Hou, W Xie, L Yu, LC Camacho, C Nie, M Zhang… - Small, 2020 - Wiley Online Library
The topographic features of an implant, which mechanically regulate cell behaviors and
functions, are critical for the clinical success in tissue regeneration. How cells sense and …

[HTML][HTML] Advances in engineering human tissue models

CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …

Double rolling circle amplification generates physically cross-linked DNA network for stem cell fishing

C Yao, H Tang, W Wu, J Tang, W Guo… - Journal of the …, 2020 - ACS Publications
Stem cells have been widely studied in cell biology and utilized in cell-based therapies, and
fishing stem cells from marrow is highly challenging due to the ultralow content. Herein, a …

Extended exposure to stiff microenvironments leads to persistent chromatin remodeling in human mesenchymal stem cells

AR Killaars, JC Grim, CJ Walker, EA Hushka… - Advanced …, 2019 - Wiley Online Library
Bone marrow derived human mesenchymal stem cells (hMSCs) are a promising cell source
for regenerative therapies; however, ex vivo expansion is often required to achieve clinically …