Population-wide tolerance and persisters enable susceptible bacterial cells to endure
hostile environments, including antimicrobial exposure. The SOS response can play a …

Bacterial biofilms are highly recalcitrant to antibiotic therapies due to multiple tolerance
mechanisms. The involvement of Pseudomonas aeruginosa in a wide range of biofilm …

Bacteria can be adapted to adverse and detrimental conditions that induce general and
specific responses to DNA damage as well as acid, heat, cold, starvation, oxidative …

Much of contemporary synthetic biology research relies on the use of bacterial chassis for
plugging-in and plugging-out genetic circuits and new-to-nature functionalities. However …

Pseudomonas aeruginosa is the most prevalent pathogen of cystic fibrosis (CF) lung
disease. Its long persistence in CF airways is associated with sophisticated mechanisms of …

One of the most terrible consequences of Darwinian evolution is arguably the emergence
and spread of antibiotic resistance, which is becoming a serious menace to modern …

Mammalian phenylalanine hydroxylase (PAH) catalyzes the rate‐limiting step in the
phenylalanine catabolism, consuming about 75% of the phenylalanine input from the diet …

When bacteria evolve resistance against a particular antibiotic, they may simultaneously
gain increased sensitivity against a second one. Such collateral sensitivity may be exploited …

The main causes of antibiotic resistance are the selection of naturally occurring resistant
variants and horizontal gene transfer processes. In recent years, the implications of antibiotic …

Emergence of epidemic clones and antibiotic resistance development compromises the
management of Pseudomonas aeruginosa cystic fibrosis (CF) chronic respiratory infections …