Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Clear cell renal cell carcinomas (ccRCCs) represent∼ 75% of RCC cases and account for
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …

Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …

As a result of evolutionary selection, the subunits of naturally occurring protein assemblies
often fit together with substantial shape complementarity to generate architectures optimal …

The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …

Non-alcoholic fatty liver disease (NAFLD) and its complications are an expanding health
problem associated with the metabolic syndrome. Liver sinusoidal endothelial cells (LSECs) …

The ang opoietin/t yrosine kinase with i mmunoglobulin and e pidermal growth factor
homology domains (Ang/Tie) pathway is an emerging key regulator in vascular development …

Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF
receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …