The role of Gβγ subunits in cellular signaling has become well established in the past 20
years. Not only do they regulate effectors once thought to be the sole targets of Gα subunits …

G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …

Heterotrimeric G proteins, composed of Gα and Gβγ subunits, transduce extracellular
signals via G-protein-coupled receptors to modulate many important intracellular responses …

Vascular dementia (VaD) is considered to be the second most common form of dementia
after Alzheimer's disease, and no specific drugs have been approved for VaD treatment. We …

Integrins are a group of heterodimeric transmembrane receptors that play essential roles in
cell–cell and cell–matrix interaction. Integrins are important in many physiological processes …

The activation of G-protein-coupled olfactory receptors on the olfactory sensory neurons
(OSNs) triggers a signaling cascade, which is mediated by a heterotrimeric G-protein …

Dopamine D1 receptors play an important role in movement, reward, and learning and are
implicated in a number of neurological and psychiatric disorders. These receptors are …

Heterotrimeric G proteins, composed of an α, β and γ subunit, represent one of the most
important and dynamic families of signaling proteins. As a testament to the significance of G …

Intracellular signaling events are often organized around PDZ (PSD-95/Drosophila Disc
large/ZO-1 homology) domain-containing scaffolding proteins. The ubiquitously expressed …

Taste is essential for the interaction of animals with their food and has co-evolved with diet.
Humans have peopled a large range of environments and present a wide range of diets, but …