Combating TKI resistance in CML by inhibiting the PI3K/Akt/mTOR pathway in combination with TKIs: A review
Chronic myeloid leukemia (CML), a myeloproliferative hematopoietic cancer, is caused by a
genetic translocation between chromosomes 9 and 22. This translocation produces a small …
genetic translocation between chromosomes 9 and 22. This translocation produces a small …
Animal models of hepatocellular carcinoma: the role of immune system and tumor microenvironment
Z Macek Jilkova, K Kurma, T Decaens - Cancers, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has
one of the highest mortality rates of solid cancers. Ninety percent of HCCs are associated …
one of the highest mortality rates of solid cancers. Ninety percent of HCCs are associated …
DEN-induced rat model reproduces key features of human hepatocellular carcinoma
Simple Summary Hepatocellular carcinoma is the most frequent form of primary liver cancer,
characterized by increasing incidence and high mortality. Animal models of hepatocellular …
characterized by increasing incidence and high mortality. Animal models of hepatocellular …
Targeting Akt in hepatocellular carcinoma and its tumor microenvironment
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related
deaths worldwide, and its incidence is rising. HCC develops almost exclusively on the …
deaths worldwide, and its incidence is rising. HCC develops almost exclusively on the …
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt
N Uhlenbrock, S Smith, J Weisner, I Landel… - Chemical …, 2019 - pubs.rsc.org
The Ser/Thr kinase Akt (Protein Kinase B/PKB) is a master switch in cellular signal
transduction pathways. Its downstream signaling influences cell proliferation, cell growth …
transduction pathways. Its downstream signaling influences cell proliferation, cell growth …
Chronic intermittent hypoxia increases cell proliferation in hepatocellular carcinoma
L Carreres, M Mercey-Ressejac, K Kurma, J Ghelfi… - Cells, 2022 - mdpi.com
Obstructive sleep apnea (OSA) syndrome is characterized by chronic intermittent hypoxia
and is associated with an increased risk of all-cause mortality, including cancer mortality …
and is associated with an increased risk of all-cause mortality, including cancer mortality …
[HTML][HTML] Combination of AKT inhibitor ARQ 092 and sorafenib potentiates inhibition of tumor progression in cirrhotic rat model of hepatocellular carcinoma
The prognosis of patients with advanced hepatocellular carcinoma (HCC) is very poor. The
AKT pathway is activated in almost half of HCC cases and in addition, long term exposure to …
AKT pathway is activated in almost half of HCC cases and in addition, long term exposure to …
Elevated expression of RIT1 hyperactivates RAS/MAPK signal and sensitizes hepatocellular carcinoma to combined treatment with sorafenib and AKT inhibitor
L Sun, S Xi, Z Zhou, F Zhang, P Hu, Y Cui, S Wu… - Oncogene, 2022 - nature.com
Hyperactivation of RAS/MAPK signaling is commonly observed in hepatocellular carcinoma
(HCC). Gain-of-function mutations of canonical RAS genes, however, are rarely detected …
(HCC). Gain-of-function mutations of canonical RAS genes, however, are rarely detected …
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment
This study was intended (1) to develop a robust animal model for hepatocellular carcinoma
(HCC) research, in which HCC tumors develop in a background of fibrosis or cirrhosis; and …
(HCC) research, in which HCC tumors develop in a background of fibrosis or cirrhosis; and …
Sorafenib alleviates inflammatory signaling of tumor microenvironment in precancerous lung injuries
According to population-based studies, lung cancer is the prominent reason for cancer-
related mortality worldwide in males and is also rising in females at an alarming rate …
related mortality worldwide in males and is also rising in females at an alarming rate …