Evidence-based diagnosis, staging, and treatment of patients with hepatocellular carcinoma

J Bruix, M Reig, M Sherman - Gastroenterology, 2016 - Elsevier
Evidence-based management of patients with hepatocellular carcinoma (HCC) is key to
their optimal care. For individuals at risk for HCC, surveillance usually involves …

Advances in targeted therapies for hepatocellular carcinoma in the genomic era

JM Llovet, A Villanueva, A Lachenmayer… - Nature reviews Clinical …, 2015 - nature.com
Mortality owing to liver cancer has increased in the past 20 years, and the latest estimates
indicate that the global health burden of this disease will continue to grow. Most patients with …

SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with advanced hepatocellular carcinoma

AX Zhu, O Rosmorduc, TRJ Evans, PJ Ross… - Journal of Clinical …, 2015 - ascopubs.org
Purpose To compare the clinical outcomes of sorafenib plus either erlotinib or placebo in
patients with advanced hepatocellular carcinoma (HCC) in a multicenter, multinational …

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

M Omata, LA Lesmana, R Tateishi, PJ Chen… - Hepatology …, 2010 - Springer
Abstract Introduction The Asian Pacific Association for the Study of the Liver (APASL)
convened an international working party on the management of hepatocellular carcinoma …

Anti-hepatocellular carcinoma biomolecules: molecular targets insights

N Juaid, A Amin, A Abdalla, K Reese, Z Alamri… - International journal of …, 2021 - mdpi.com
This report explores the available curative molecules directed against hepatocellular
carcinoma (HCC). Limited efficiency as well as other drawbacks of existing molecules led to …

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

S Whittaker, R Marais, AX Zhu - Oncogene, 2010 - nature.com
Hepatocellular carcinoma (HCC) is a highly prevalent, treatment-resistant malignancy with a
multifaceted molecular pathogenesis. Current evidence indicates that during …

Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design

JM Llovet, V Hernandez-Gea - Clinical cancer research, 2014 - AACR
Hepatocellular carcinoma (HCC) is a major health problem. Most patients with HCC
experience a recurrence after resection/ablation or are diagnosed at advanced stages …

[HTML][HTML] Cirrhosis and its complications: evidence based treatment

S Nusrat, MS Khan, J Fazili… - World Journal of …, 2014 - ncbi.nlm.nih.gov
Cirrhosis results from progressive fibrosis and is the final outcome of all chronic liver
disease. It is among the ten leading causes of death in United States. Cirrhosis can result in …

[PDF][PDF] Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

BC Fuchs, Y Hoshida, T Fujii, L Wei, S Yamada… - …, 2014 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related
mortality in the United States. Because of the lack of viable treatment options for HCC …

Hepatocellular carcinoma: current management and perspectives for the future

NN Rahbari, A Mehrabi, NM Mollberg, SA Müller… - Annals of …, 2011 - journals.lww.com
Objective: To review the literature on current management of hepatocellular carcinoma
(HCC). Background: Hepatocellular carcinoma represents one of the most common …