Idiopathic pulmonary fibrosis is a progressive and usually fatal lung disease characterized
by fibroblast proliferation and extracellular matrix remodeling, which result in irreversible …

Bioscaffolds derived from xenogeneic extracellular matrix (ECM) have been used in
numerous tissue engineering applications. The safety and efficacy of such scaffolds when …

The extracellular matrix (ECM) consists of a complex mixture of structural and functional
proteins and serves an important role in tissue and organ morphogenesis, maintenance of …

Tissue inhibitor of metalloproteinases-3 (TIMP3) is one of four members of a family of
proteins that were originally classified according to their ability to inhibit matrix …

Extracellular matrix (ECM) is known to provide signals controlling cell shape, migration,
proliferation, differentiation, morphogenesis, and survival. Recent data shows that some of …

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that function to
maintain and remodel tissue architecture. Their substrates represent an astounding variety …

Matrix metalloproteinases (MMPs) are matrixdegrading enzymes involved in diverse
homeostatic and pathological processes. Several MMPs are expressed within the CNS and …

Evidence is provided that proteolytic cleavage of collagen type IV results in the exposure of
a functionally important cryptic site hidden within its triple helical structure. Exposure of this …

Vascularization of the growth plate region represents a key mechanism for the coupling of
two fundamental processes determing the rate of bone growth, chondrogenesis (cartilage …

Written by more than 400 subject experts representing diverse academic and applied
domains, this multidisciplinary resource surveys the vanguard of biomaterials and …