Management of Acute and Recurrent Pericarditis: JACC State-of-the-Art Review

JG Chiabrando, A Bonaventura, A Vecchié… - Journal of the American …, 2020 - jacc.org
Pericarditis refers to the inflammation of the pericardial layers, resulting from a variety of
stimuli triggering a stereotyped immune response, and characterized by chest pain …

Interleukin-1 beta as a target for atherosclerosis therapy: biological basis of CANTOS and beyond

P Libby - Journal of the American College of Cardiology, 2017 - jacc.org
Inflammatory pathways drive atherogenesis and link conventional risk factors to
atherosclerosis and its complications. One inflammatory mediator has come to the fore as a …

The NLRP3 inflammasome in acute myocardial infarction

S Toldo, A Abbate - Nature Reviews Cardiology, 2018 - nature.com
The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases

S Toldo, A Abbate - Nature Reviews Cardiology, 2024 - nature.com
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Post-Stroke Cardiovascular Complications and Neurogenic Cardiac Injury: JACC State-of-the-Art Review

LA Sposato, MJ Hilz, S Aspberg, SB Murthy… - Journal of the american …, 2020 - jacc.org
Over 1.5 million deaths worldwide are caused by neurocardiogenic syndromes.
Furthermore, the consequences of deleterious brain-heart interactions are not limited to fatal …

From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection

PM Ridker - Circulation research, 2016 - Am Heart Assoc
Plasma levels of the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP)
predict vascular risk with an effect estimate as large as that of total or high-density …

The inflammatory response in myocardial injury, repair, and remodelling

NG Frangogiannis - Nature Reviews Cardiology, 2014 - nature.com
Myocardial infarction triggers an intense inflammatory response that is essential for cardiac
repair, but which is also implicated in the pathogenesis of postinfarction remodelling and …

Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction

PC Westman, MJ Lipinski, D Luger, R Waksman… - Journal of the American …, 2016 - jacc.org
Abstract Treatment of acute myocardial infarction (AMI) has improved significantly in recent
years, but many patients have adverse left ventricular (LV) remodeling, a maladaptive …

Anticytokine agents: targeting interleukin signaling pathways for the treatment of atherothrombosis

PM Ridker - Circulation research, 2019 - Am Heart Assoc
The recognition that atherosclerosis is a complex chronic inflammatory disorder mediated
through both adaptive and innate immunity has led to the hypothesis that anticytokine …

Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases

D Liu, X Zeng, X Li, JL Mehta, X Wang - Basic research in cardiology, 2018 - Springer
NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls
inflammatory responses and coordinates antimicrobial host defenses by activating caspase …