ABSTRACT DNA methylation (DNAm) is one of the most studied epigenetic modifications.
DNAm has emerged as a key biological mechanism and biomarkers to test associations …

Maternal diabetes and/or obesity in pregnancy are undoubtedly associated with later
disease-risk in the offspring. The placenta, interposed between the mother and the foetus, is …

Objective Fetal exposures may impact offspring epigenetic signatures and adiposity. The
authors hypothesized that maternal metabolic traits associate with cord blood DNA …

Aims Gestational diabetes mellitus (GDM) can lead to short-and long-term complications for
the child. Epigenetic alterations could contribute to explaining the metabolic disturbances …

Background Epigenetics can contribute to lipid disorders in obesity. The DNA methylation
pattern can be the cause or consequence of high blood lipids. The aim of the study was to …

Epigenetics is the study of changes in gene expression, without a change in the DNA
sequence that are potentially heritable. Epigenetic mechanisms such as DNA methylation …

Maternal obesity is associated with fetal complications predisposing later to the
development of metabolic syndrome during childhood and adult stages. High-fat diet seems …

Epigenome-wide association studies (EWAS) have provided opportunities to understand the
role of epigenetic mechanisms in development and pathophysiology of many chronic …

Introduction The ability to identify early epigenetic signatures underlying the inheritance of
cardiovascular risk, including trans-and intergenerational effects, may help to stratify people …

Mémoire présenté à la Faculté de médecine et des sciences de la santé en vue de
l'obtention du diplôme de maitre ès sciences (M. Sc.) en Biochimie et génomique …