Major risks conferred by BRCA1 and BRCA2 in women are for cancers of the breast, ovary,
fallopian tube, and peritoneum. Male carriers of mutations in BRCA1 or BRCA2 are also …

Genetic susceptibility to breast cancer in women is conferred by a large number of genes, of
which six have so far been identified. In the context of multiple-case families, BRCA1 and …

Background: Germline BRCA1 mutations confer a substantial lifetime risk of breast and
ovarian cancer, but whether cancer at other sites is increased is less clear. To evaluate the …

Purpose: Increased prostate cancer risk has been reported for BRCA mutation carriers, but
BRCA-associated clinicopathologic features have not been clearly defined. Experimental …

Objective Evidence shows that gene mutation is a significant proportion of genetic factors
associated with prostate cancer. The DNA damage response (DDR) is a signal cascade …

Studies of families with breast cancer have indicated that male carriers of BRCA2 mutations
are at increased risk of prostate cancer, particularly at an early age. To evaluate the …

The DNA-damage–signaling pathway has been implicated in all human cancers. However,
the genetic defects and the mechanisms of this pathway in prostate carcinogenesis remain …

Purpose: Protein-truncating mutations in BRCA1 and in particular BRCA2 genes have been
associated with prostate cancer. However, there is still uncertainty about the magnitude of …

To evaluate whether an inactivating mutation in the gene for the Nijmegen breakage
syndrome (NBS1) plays a role in the etiology of prostate cancer, we compared the …

Variants in the CHEK2 have been found to be associated with prostate cancer risk in the
United States and Finland. We sequenced CHEK2 gene in 140 Polish patients with prostate …