Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …

Brain malignancies can either originate from within the CNS (gliomas) or invade from other
locations in the body (metastases). A highly immunosuppressive tumor microenvironment …

T cells are critical effectors of cancer immunotherapies, but little is known about their gene
expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing …

Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by
innate immune-mediated inflammation, but functional and mechanistic effects of the …

Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A …

The brain is a site of relative immune privilege. Although CD4 T cells have been reported in
the central nervous system, their presence in the healthy brain remains controversial, and …

In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …

Abstract α-Synuclein, a key pathological component of Parkinson's disease, has been
implicated in the activation of the innate and adaptive immune system. This immune …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …