Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …

The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …

Checkpoint blockade with antibodies specific for the PD-1 and CTLA-4 inhibitory receptors
can induce durable responses in a wide range of human cancers. However, the …

Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

The gastrointestinal tract is a specialized organ in which dynamic interactions between host
cells and the complex environment occur in addition to food digestion. Together with the …

Over the past two decades, the importance of the microbiota in health and disease has
become evident. Pathological changes to the oral bacterial microbiota, such as those …

Host-microbial cross-talk plays a crucial role in maintenance of gut homeostasis. However,
how microbiota-derived metabolites, eg, butyrate, regulate functions of neutrophils in the …