I. Introduction A ngiotensin (ANG II) was discovered about 50 yr ago (1, 2), and a complete
peripheral system for the formation and metabolism of ANG II was soon characterized. It was …

1. Introduction direct injection of Ang II into the rat brain produced drinking behavior [9] and
indirect measurements showing Exactly one hundred years ago Tiegerstedt and Bergman …

Synopsis: Captopril 1 is the first orally active inhibitor of angiotensin-converting enzyme to
become available. It has been studied to date primarily in hypertension. In mild to moderate …

Considerable evidence now indicates that a separate and distinct renin-angiotensin system
(RAS) is present within the brain. The necessary precursors and enzymes required for the …

To determine the role of angiotensinogen and angiotensin II type-1 (AT1) receptor genes in
hypertension, spontaneously hypertensive rats (SHR) were injected with synthetic antisense …

In addition to the circulatory renin (REN)–angiotensin system (RAS), a tissue RAS having an
important role in cardiovascular function also exists in the central nervous system. In the …

We studied the density of the angiotensin II (Ang II) binding site in discrete brain nuclei of 4-
week-old and 14-week-old spontaneously hypertensive rats (SHR) and agematched …

Volumes 7 and 8 of the Handbook were published in 1977. In Volume 7 methods for
studying unconditioned and conditioned behavior were reviewed. Attention was given to …

Atrial natriuretic peptides, produced in the mammalian cardiac atrium, are released into the
general circulation and may be actively involved in the control of blood pressure and in fluid …

Phosphorothioated antisense oligodeoxynucleotide (ASODN) targeted to angiotensinogen
mRNA was administered intracerebroventricularly in spontaneously hypertensive rats to test …