The effects of various doses of the converting enzyme inhibitor captopril injected into the
lateral brain ventricle (icv) and intravenously (iv) on blood pressure (BP) and on converting …

Publisher Summary This chapter reviews substantial anatomical data describing the
distribution of bradykinin (BK) receptors as well as that of the biochemical machinery for the …

This study investigated the effects of captopril, hydralazine and losartan on the locomotor
activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their …

Angiotensin II binding sites were localized and quantified in individual brain nuclei from
single rats by incubation of tissue sections with 1 nM 125 I-[Sar 1]-angiotensin II,[3 H] …

With advances in genetic manipulation and molecular biological and physiological
techniques, the mouse has become the animal model of choice for studying the genetic …

Introduction: The renin–angiotensin–aldosterone system (RAAS) is already the most
important target for drugs in the cardiovascular system. However, still new developments are …

Captopril infused into the lateral ventricle (ICV) of adult spontaneously hypertensive rats
(SHR) decreases blood pressure. The current study was designed to explore the effects of …

Several lines of evidence indicate brain angiotensin II is associated with the elevation of
blood pressure seen in the spontaneously hypertensive rat (SHR). These include an …

An overactive brain renin-angiotensin system is one of the factors contributing to the
pathogenesis of hypertension in spontaneously hypertensive rats (SHR). We examined …

The hydrolysis of the new converting enzyme (CE) inhibitor MK 421 to its more active diacid
form (MK-diacid) was studied by measuring CE inhibition in rat plasma and in some target …