Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …

Subendothelial collagen exposed to platelets after rupture of atherosclerotic plaques is the
main trigger of platelet activation und acute arterial thrombotic occlusion leading to …

Mass spectrometry (MS)-based targeted lipidomics enables the robust quantification of
selected lipids under various biological conditions but comprehensive software tools to …

Platelet integrity and function critically depend on lipid composition. However, the lipid
inventory in platelets was hitherto not quantified. Here, we examined the lipidome of murine …

Platelet activation plays a critical role in thrombosis. Inhibition of platelet activation is a
cornerstone in treatment of acute organ ischemia. Platelet ACKR3 surface expression is …

During megakaryopoiesis, megakaryocytes (MKs) undergo cellular morphological changes
with strong modification of membrane composition and lipid signaling. Here, we adopt a lipid …

Background: Platelets can infiltrate ischemic myocardium and are increasingly recognized
as critical regulators of inflammatory processes during myocardial ischemia and reperfusion …

The function of platelets–and thereby the balance between thrombosis and hemostasis–
critically depends on their lipid composition. At the same time, platelets are capable of …

Aims Beyond classical roles in thrombosis and haemostasis, it becomes increasingly clear
that platelets contribute as key players to inflammatory processes. The involvement of …

Rationale: Platelet activation after contact to subendothelial collagen leads to acute arterial
thrombosis. ANXA7 (Annexin A7) is a phospholipid-binding protein participating in the …