The acute inflammatory response is a double-edged sword. On the one hand, it plays a key
role in initial host defense, particularly against many infections. On the other hand, its aim is …

When cells die in vivo, they trigger an inflammatory response. The ensuing hyperemia, leak
of plasma proteins, and recruitment of leukocytes serve a number of useful functions in host …

Mucosal repair is a complex event that immediately follows acute injury induced by ischemia
and noxious luminal contents such as bile. In the small intestine, villous contraction is the …

Granulocyte colony-stimulating factor (G-CSF) mediates “emergency” granulopoiesis during
infection, a process that is mimicked by clinical G-CSF use, yet we understand little about the …

A complete blood cell count (CBC) is one of the most common laboratory tests in medicine.
For example, at our institution alone, approximately 1800 CBCs are ordered every day, and …

Heterozygous mutations of the gene encoding neutrophil elastase (ELA2) have been
associated with cyclic neutropenia (CN) and severe congenital neutropenia (SCN). To date …

Intestinal ischemia is a frequently observed phenomenon. Morbidity and mortality rates are
extraordinarily high and did not improve over the past decades. This is in part attributable to …

White blood cells, WBCs for short, are an essential component of the human immune
system. These cells are our body's first line of defense against infections and diseases …

Abstract Background The Severe Chronic Neutropenia International Registry (SCNIR) was
organized 10 years ago to improve understanding and treatment of the group of rare …

Multiple immunotherapeutics have been approved for cancer patients, however advanced
solid tumors are frequently refractory to treatment. We evaluated the safety and …