Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections

U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Current scenario of quinolone hybrids with potential antibacterial activity against ESKAPE pathogens

J Gao, H Hou, F Gao - European Journal of Medicinal Chemistry, 2023 - Elsevier
Abstract The ESKAPE (Escherichia coli/E. coli, Staphylococcus aureus/S. aureus, Klebsiella
pneumonia/K. pneumoniae, Acinetobacter Baumannii/A. baumannii, Pseudomonas …

Specific chemiluminescence imaging and enhanced photodynamic therapy of bacterial infections by hemin‐modified carbon dots

K Cheng, H Wang, S Sun, M Wu, H Shen, K Chen… - Small, 2023 - Wiley Online Library
Antibacterial photodynamic therapy (aPDT) is a promising antibiotics‐alternative strategy for
bacterial infectious diseases, which features broad‐spectrum antibacterial activity with a low …

Shining Light on Multidrug‐Resistant Bacterial Infections: Rational Design of Multifunctional Organosilver‐Based AIEgen Probes as Light‐Activated Theranostics for …

X Liu, Y Ren, D Fan, S Huang, Y Ma… - Advanced Functional …, 2023 - Wiley Online Library
The intricate environment of biofilms provides a heaven for bacteria to escape antibiotic
eradication, leading to persistent chronic infections. Therefore, it is urgently needed to …

Antibacterial theranostic agents with negligible living cell invasiveness: AIE-active cationic amphiphiles regulated by alkyl chain engineering

Z Zhuang, Z Meng, J Li, P Shen, J Dai, X Lou, F Xia… - ACS …, 2022 - ACS Publications
To address the threat of bacterial infection in the following post-antibiotic era, developing
effective antibacterial approaches is of utmost urgency. Theranostic medicine integrating …

A chitosan-based self-healing hydrogel for accelerating infected wound healing

H Cui, B Cui, H Chen, X Geng, X Geng, Z Li… - Biomaterials …, 2023 - pubs.rsc.org
Wound infection causes irregular tissue closure, often with prolonged healing. Traditional
therapies based on antibiotic delivery have resulted in reduced therapeutic efficiency and …

Aloe emodin-conjugated sulfonyl hydrazones as novel type of antibacterial modulators against S. aureus 25923 through multifaceted synergistic effects

Z Deng, RRY Bheemanaboina, Y Luo, CH Zhou - Bioorganic Chemistry, 2022 - Elsevier
Aloe emodin-conjugated sulfonyl hydrazones were designed and synthesized as novel type
of antibacterial modulators. Aloe emodin benzenesulfonyl hydrazone 5a (AEBH-5a) was …

Antibacterial fabrics based on synergy of piezoelectric effect and physical interaction

Y Wang, KK Liu, WB Zhao, JL Sun, XX Chen, LL Zhang… - Nano Today, 2023 - Elsevier
Antibacterial clothes play a key role in reducing the spreading threat of bacteria, thus
protecting people's health. In this work, several kinds of fabrics with high antibacterial …

Six‐Pointed Star Chiral Cobalt Superstructures with Strong Antibacterial Activity

G Wang, C Hao, C Chen, H Kuang, C Xu, L Xu - Small, 2022 - Wiley Online Library
Chiral inorganic nanomaterials have shown promise as a potential means of combating
bacteria due to their high levels of biocompatibility, easy surface modification, and excellent …

ε‐poly‐L‐lysine‐modified polydopamine nanoparticles for targeted photothermal therapy of drug‐resistant bacterial keratitis

W Fan, H Han, Z Lu, Y Huang, Y Zhang… - Bioengineering & …, 2023 - Wiley Online Library
Bacterial keratitis can lead to intraocular infection and even blindness without prompt and
potent treatments. Currently, clinical abuse of antibiotics encouraged the evolution of …