The endocannabinoid system: a potential target for the treatment of various diseases
H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …
balance in internal environment (temperature, mood, and immune system) and energy input …
[HTML][HTML] Cannabinoids as therapeutic agents in cancer: current status and future implications
B Chakravarti, J Ravi, RK Ganju - Oncotarget, 2014 - ncbi.nlm.nih.gov
The pharmacological importance of cannabinoids has been in study for several years.
Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant,(b) …
Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant,(b) …
The endocannabinoid system and cancer: therapeutic implication
J Guindon, AG Hohmann - British journal of pharmacology, 2011 - Wiley Online Library
The endocannabinoid system is implicated in a variety of physiological and pathological
conditions (inflammation, immunomodulation, analgesia, cancer and others). The main …
conditions (inflammation, immunomodulation, analgesia, cancer and others). The main …
Opportunities for cannabis in supportive care in cancer
Cannabis has the potential to modulate some of the most common and debilitating
symptoms of cancer and its treatments, including nausea and vomiting, loss of appetite, and …
symptoms of cancer and its treatments, including nausea and vomiting, loss of appetite, and …
The endocannabinoid/endovanilloid system in bone: from osteoporosis to osteosarcoma
Bone is a dynamic tissue, whose homeostasis is maintained by a fine balance between
osteoclast (OC) and osteoblast (OB) activity. The endocannabinoid/endovanilloid (EC/EV) …
osteoclast (OC) and osteoblast (OB) activity. The endocannabinoid/endovanilloid (EC/EV) …
Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists
SA Grenald, MA Young, Y Wang, MH Ossipov… - …, 2017 - Elsevier
The misuse of prescription opiates is on the rise with combination therapies (eg
acetaminophen or NSAIDs) resulting in severe liver and kidney damage. In recent years …
acetaminophen or NSAIDs) resulting in severe liver and kidney damage. In recent years …
Update on cannabis and cannabinoids for cancer pain
To date, preclinical data has demonstrated evidence to suggest promising potential for
cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to …
cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to …
The neurobiology of cancer pain
BL Schmidt - The Neuroscientist, 2014 - journals.sagepub.com
The global burden of cancer pain is enormous and opioids, despite their side effects, remain
the primary therapeutic approach. The cause of cancer pain is unknown. Mechanisms …
the primary therapeutic approach. The cause of cancer pain is unknown. Mechanisms …
Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and …
T Khunluck, K Lertsuwan, C Chutoe… - Scientific Reports, 2022 - nature.com
The endocannabinoid system has been postulated to help restrict cancer progression and
maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid …
maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid …
Dynamic changes to the endocannabinoid system in models of chronic pain
D Rani Sagar, JJ Burston… - … of the Royal …, 2012 - royalsocietypublishing.org
The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well
established. However, the side-effect profile of CB1 receptor ligands has necessitated the …
established. However, the side-effect profile of CB1 receptor ligands has necessitated the …