The cannabinoid receptor type 1, found mainly on cells of the central and peripheral nervous
system, is a major component of the endogenous cannabinoid system. Constitutive and …

The stimulation of spinal cannabinoid type 2 (CB2) receptors is a suitable strategy for the
alleviation of experimental pain symptoms. Several reports have described the up-regulation …

A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and
synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a …

Novel interest has arisen in recent years regarding bone, which is a very complex and
dynamic tissue deputed to several functions ranging from mechanical and protective support …

G protein coupled receptors (GPCRs) are key players in signal recognition and cellular
communication making them important therapeutic targets. Large-scale production of these …

Bone is a highly complex and metabolically active tissue undergoing a continuous
remodeling process, which endures throughout life. A complex cell-signaling system that …

Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to
control. Pain originating in the bone can be caused by many different entities including …

Bone pain is a common symptom in bone metastases. The therapies that are currently
available include nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, steroids and …

Treatments for painful osseous metastases may not only diminish pain, but also may
improve quality of life and independence/mobility, and reduce skeletal morbidity, potential …

Introduction: Current treatment for metastatic bone pain is mainly palliative. Recent insights
into the molecular mechanisms involved in bone metastases have led to the identification of …