Multivalent Cathepsin Inhibitor, VBY-825, Attenuates Breast-Induced Bone Cancer Remodelling and Pain

T Nikolich-Zugich - 2013 - repository.arizona.edu
Metastatic bone cancer originates from breast malignancies causing severe pain and bone
destruction in patients. Amongst the novel therapies under clinical development for the …

[图书][B] Novel mechanisms and therapeutics in the treatment for cancer-induced bone pain

AN Ondoua - 2013 - search.proquest.com
Many common cancers, including breast, prostate and lung, have a predilection to
metastasize to the bone, bringing not only bone destruction but severe pain. Although novel …

Pain Relief in Metastatic Cancer

O Spruyt, N Michael - Prostate Cancer: A Comprehensive Perspective, 2012 - Springer
The competent management of pain in patients with advanced cancer draws upon in-depth
knowledge of cancer and its complications, diagnostic acumen, expertise in the …

Functional human Cannabinoid Receptor 2 from Escherichia coli

A Chowdhury - 2013 - search.proquest.com
Abstract The Cannabinoid Receptor 2 (CB2), a member of the endocannabinoid system
belongs to the Rhodopsin family of G-Protein Coupled Receptors (GPCRs). It is expressed …

[PDF][PDF] Research Article The Cannabinoid Receptor Type 1 Is Essential for Mesenchymal Stem Cell Survival and Differentiation: Implications for Bone Health

A Gowran, K McKayed, VA Campbell - 2013 - academia.edu
Significant loss of bone due to trauma, underlying metabolic disease, or lack of repair due to
old age surpasses the body's endogenous bone repair mechanisms. Mesenchymal stem …

[PDF][PDF] Évaluation comportementale et imagerie d'un nouveau modèle murin de douleur cancéreuse osseuse et exploration du potentiel analgésique des agonistes …

L Doré-Savard - 2012 - core.ac.uk
Résumé Une personne sur trois sera diagnostiquée d'un cancer au cours de sa vie. Malgré
les progrès importants dans le développement de traitements anti-cancéreux, de nombreux …

[PDF][PDF] The cannabinoid CB2 receptor as a target for the treatment of neuropathic pain

PW Brownjohn - 2012 - Citeseer
Cannabinoids are cannabis-like drugs that are moderately efficacious in the treatment of
some types of chronic pain, including pain of a neuropathic origin. Limiting their therapeutic …

Chronic cancer pain models: bone metastasis

DL Voisin, Y Lefèvre, VRR Ducourneau, A Amadio… - Douleur et …, 2012 - Springer
Bone cancer pain is very common and patients with this type of pain may be difficult to treat.
Recent animal model of bone cancer that mirror the clinical picture of patients with cancer …

Emerging analgesics and future directions: targeting neuroplasticity

AN Lozano-Ondoua, TW Vanderah - 2012 - Taylor & Francis
Quality of life is defined as an individual's perception of their culture and values, as well as
their goals, morals and concerns. Pain induced by progression of disease and adverse …

Cannabinoid Receptor 2: A Novel Multi-Targeted Approach in the Treatment of Breast Cancer and Related Skeletal Metastasis

KE Hanlon - 2012 - repository.arizona.edu
Breast cancer, which in advanced stages often leads to bone metastasis, is the most
frequent malignant tumor and the second deadliest form of cancer among women in the US …