COPD is now widely recognized as a complex heterogeneous syndrome, having both
pulmonary and extrapulmonary features. In clinical practice, the diagnosis of COPD is based …

Background Lung volume reduction surgery (LVRS) performed to treat patients with severe
diffuse emphysema was reintroduced in the nineties. Lung volume reduction surgery aims to …

Background Emphysema and small airway disease both contribute to chronic obstructive
pulmonary disease (COPD), a disease characterised by accelerated decline in lung …

Background Development of emphysema and vascular stiffness in chronic obstructive
pulmonary disease (COPD) may be due to a common mechanism of susceptibility to …

Objectives: The objective of this study was to evaluate an artificial intelligence (AI)-based
prototype algorithm for the fully automated per lobe segmentation and emphysema …

BACKGROUND: Matrix metalloproteinase (MMP)-12 has been implicated in the
pathogenesis of both chronic obstructive pulmonary disease (COPD) and asthma. The …

Background The authors of previous reports have suggested that women are more
susceptible to cigarette smoke and to an airway-predominant COPD phenotype rather than …

BACKGROUND: COPD patients have varying degrees of airways disease and emphysema.
CT scanning can differentiate these pathological subtypes. We evaluated airway dimensions …

Chronic obstructive pulmonary disease (COPD) is a complex and multi-component
respiratory disease. Computed tomography (CT) images can characterize lesions in COPD …

Rationale: Emphysema has considerable variability in the severity and distribution of
parenchymal destruction throughout the lungs. Upper lobe–predominant emphysema has …